新型暂堵酸化用自降解暂堵剂的制备及现场应用

针对传统暂堵酸化用暂堵剂颗粒耐酸性差、降解性差和除堵工艺复杂等问题，本研究通过水溶液自由基聚合法制备了一种新型的自降解暂堵剂CQZDJ。考察了单体加量、交联剂加量、引发剂加量对CQZDJ凝胶强度和降解性的影响；通过FT-IR、TGA、SEM对其结构进行表征；并对其降解机理进行了探讨；最后在长8区块的环平81-8实验井进行了现场实践。结果表明：CQZDJ凝胶强度及降解时间与单体加量、交联剂加量、引发剂加量成正比关系，且降解时间可控；降解性实验表明CQZDJ在(1%~10%)HCl溶液、水、（2%~10%）NaCl溶液中均可在4 d内完全降解，具备良好的降解性能，对地层伤害小；SEM照片显示CQZDJ的降解过程是从初始三维网状结构逐渐崩解为层状结构，最终降解为无规则线性小分子链的过程；暂堵后现场流压上升6.3 MPa，日产油由3.87 t/d增产至5.22 t/d，实现了储层的有效改造，增产效果显著。      

Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral γ-Amino Alcohols

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral γ-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral γ-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 % ee).     

立方相KNbO3晶体本征空位点缺陷的电子结构研究

利用第一性原理从头计算方法对立方相KNbO3晶体的肖特基缺陷的稳定性、能带结构、电子态密度和磁性性质进行了研究.发现含本征点缺陷的KNbO3体系结构稳定;K,Nb空位诱导KNbO3缺陷晶体产生铁磁性;O空位则无此性质.K空位诱导KNbO3缺陷晶体磁性源于O原子2p轨道退简并;Nb空位诱导KNbO3缺陷晶体磁性源于O-2p电子极化.     

语音通信降噪研究

语音通信系统中，语音通过信道传输将不可避免地引入码间串扰和信号畸变，同时受到噪声污染。本文在分析自适应盲均衡算法CMA(constant modulus algorithm）和改进盲均衡算法的基础上，考虑到自适应盲均衡技术在语音噪声控制方面能力有限，将自适应盲均衡技术与小波包掩蔽阈值降噪算法联合使用，形成一种基带语音增强新方法。仿真试验结果显示自适应盲均衡技术可以使星座图变得清晰而紧凑，有效减小误码率。研究证实该方法在语音信号ISI和畸变严重情况下，在白噪及有色噪声不同的噪声环境中都具有稳定的降噪能力，消噪同时可获得汉语普通话良好的听觉效果。     

3-甲基-4-对甲基苯基-5-(2-吡啶)-1,2,4-三唑桥联的双核铜配合物的磁性理论研究

采用对称性破损态方法结合密度泛函理论,选用反铁磁双核配合物[Cu2(MMBPT)2Cl4(H2O)2.5](MMBPT=3-甲基-4-对甲基苯基-5-(2-吡啶)-1,2,4-三唑)作为研究对象,通过与实验数据相比较,探讨了不同密度泛函方法与基组对计算铜配合物交换耦合常数的准确度.结果表明,4种混合密度泛函DFT(B3LYP,B3P86,B3PW91和PBE0)的计算结果都能和实验所观察到的值-31cm-1符号一致,但只有B3PW91方法得到的结果和实验结果吻合程度最好,同时采用方法B3PW91方法计算所得的交换耦合常数Jab对基组的依赖性较大.研究表明,2个Cu(Ⅱ)离子之间弱的反铁磁相互作用主要源于单占据分子轨道SOMOs小的能量劈裂.     

两类图的(d,1)-全标号

主要讨论了W_n与C_m的笛卡尔积和均衡完全r-部图K_r(n)的(d,1)-全标号,并得出了(d,1)-全数λ_d~T(W_n□C_m)和λ_d~T(K_(r(n)))的确切值.     

Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

Despite metal-based photosensitizers showing great potential in photodynamic therapy for tumor treatment, the application of the photosensitizers is intrinsically limited by their poor cancer-targeting properties. Herein, we reported a metal-based photosensitizer-bacteria hybrid, Ir-HEcN , via covalent labeling of an iridium(III) photosensitizer to the surface of genetically engineered bacteria. Due to its intrinsic self-propelled motility and hypoxia tropism, Ir-HEcN selectively targets and penetrates deeply into tumor tissues. Importantly, Ir-HEcN is capable of inducing pyroptosis and immunogenic cell death of tumor cells under irradiation, thereby remarkably evoking anti-tumor innate and adaptive immune responses in vivo and leading to the regression of solid tumors via combinational photodynamic therapy and immunotherapy. To the best of our knowledge, Ir-HEcN is the first metal complex decorated bacteria for enhanced photodynamic immunotherapy.     

框架核酸高通量检测芯片

构建了一种基于框架核酸的高通量生物检测芯片.利用超微量移液自动化平台,将包含框架核酸探针的液滴按照预设命令固定至生物芯片微阵列上,在探针捕获核酸靶标后利用集成的基因芯片扫描仪对芯片进行成像,通过分析荧光强度定量化分析靶标浓度.结果表明,此框架核酸芯片能够实现框架核酸探针的高通量制备, 24 h即可制备具有15万个点的微阵列,且点间距离的相对偏差W≤10%、荧光强度的变异系数CV=3.30%,具有较高的稳定性,远高于国家标准.此外,该芯片具备高灵敏度、可寻址的高通量生物分析能力,对核酸靶标的检测限可达100 pmol/L.随着多种探针技术的发展,生物检测微阵列技术在高通量生物分析领域展示出巨大的潜力.     

Metal and organo-catalysed asymmetric hydroaminomethylation of styrenes

A new protocol that enables asymmetric hydroaminomethylation of styrenes to afford chiral amines has been developed. Catalysed by an Rh-phosphine species and a chiral phosphoric acid, styrenes are converted into β-chiral amines with good enantioselectivities under syngas in the presence of an amine and Hantzsch ester. The reaction involves two key steps, hydroformylation and reductive amination, with the former catalysed by the Rh species whilst the latter by the phosphoric acid.     

Sr_2CeO_4:Nd~(3+)纳米粒子的合成和近红外发光

采用甘氨酸-硝酸盐燃烧法制备了Sr2CeO4和Sr2CeO4:Nd3+发光纳米粒子。样品的结构及性质采用XRD,TEM,荧光光谱及荧光衰减曲线等进行表征。在1200℃煅烧1h能够得到均匀的类球形Sr2CeO4:Nd3+纳米粒子,其粒径大小为20~40nm,并具有良好的分散性和高效的近红外发光特性。Nd3+合适掺杂浓度为0.15%(摩尔分数)。对Sr2CeO4:Nd3+近红外发光的机制分析表明:通过基质Sr2CeO4吸收紫外光,基团CeO4发生了电荷转移达到激发态,并将激发态能量传递给了Nd3+,从而使Sr2CeO4:Nd3+产生了特征的近红外发射。